Welcome to VulExMap

VulExMap is a tool that allows the user to identify constitutive exons, that are vulnerable to splicing mutations.

The tool plots mRNA splicing data using Snaptron junction-counts from one of the following dataset:
GTEx: ~30 million junctions from ~10 thousand public samples from the GTEx project
TCGA: ~36 million junctions from ~11 thousand public samples from the TCGA project

In the Gene table you can select the gene you wish to plot.
All segments in the chosen gene are categorized as either Resilient, Vulnerable, Alternative, or not spliced in,
unless no junction counts representing the splicing of the segment were available.

Vulnerability is based on PSI as well as the coefficent of variation (CV) between the samples.
Furthermore, we have opted to exclude samples with a mean count below the assigned threshold (minimum total segment count).
When you have plotted your gene of interest, you can compare the result in the different datasets.

A BED6 file can be uploaded with mutations, to investigate if the mutations are in a vulnerable exon
and may have a higher chance of causing aberrant splicing.

Note to Firefox users: We have noticed some issues when using Firefox, such as unresponsive buttons and spurious loss of connection to the server. Usually these are resolved by simply refreshing the browser window.